Question 1 · Hard
A 4-year-old has puffy eyes and swollen legs for one week. Urine: protein 4+, no red cells. Serum albumin 1.8 g/dL (normal 3.5-5), cholesterol 380 mg/dL (normal below 200), blood pressure 96/60 mmHg. The most likely diagnosis is:
- ACongestive cardiac failure
- BNephrotic syndrome
- CAcute post-streptococcal glomerulonephritis
- DAcute pyelonephritis
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Answer: B · Nephrotic syndrome
Heavy proteinuria, albumin below 2.5 g/dL, oedema and high cholesterol are the four features of nephrotic syndrome. Normal blood pressure and no haematuria make minimal change disease the likely type in a 4-year-old. Albumin is lost in the urine, plasma oncotic pressure falls and fluid moves into the tissues, starting around the eyes. The liver makes more lipoprotein, which raises the cholesterol.
- A: Heart failure does not cause 4+ proteinuria and very low albumin.
- C: Post-streptococcal GN gives haematuria, hypertension and oliguria, with only mild proteinuria.
- D: Pyelonephritis gives fever and pyuria, not massive proteinuria.