Question 1 · Medium
A woman with severe pre-eclampsia has a postpartum haemorrhage from uterine atony. Which uterotonic should be avoided?
- AMisoprostol
- BMethylergometrine
- COxytocin
- DCarboprost
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Answer: B · Methylergometrine
Methylergometrine contracts vascular smooth muscle as well as the uterus, so it can cause a sharp rise in BP, stroke or eclampsia in a hypertensive woman. It is contraindicated in pre-eclampsia, hypertension and heart disease. Oxytocin is the first-line uterotonic, and misoprostol or carboprost can be added. Carboprost is avoided in asthma, which is not the issue here.
- A: Misoprostol does not raise BP and can be used.
- C: Oxytocin is the first-line drug for PPH and is safe in pre-eclampsia.
- D: Carboprost is avoided in asthma, not in hypertension.