Question 1 · Hard
A 3-month-old, exclusively breastfed, is brought with a hoarse, almost silent cry, fast breathing, a rapid pulse, puffy face and an enlarged liver. The mother eats mainly highly polished rice and has numbness of her feet. Deficiency of which vitamin best explains the infant's illness?
- ACobalamin (vitamin B12)
- BRiboflavin (vitamin B2)
- CThiamine (vitamin B1)
- DNiacin (vitamin B3)
Show answerHide answer
Answer: C · Thiamine (vitamin B1)
Infantile beriberi strikes breastfed babies of 2-6 months whose mothers are thiamine deficient, often from a polished-rice diet. The acute form causes aphonia (a silent cry from laryngeal nerve involvement), tachycardia, oedema and cardiac failure, and it can be fatal within hours. The mother's numb feet suggest her own dry beriberi. Thiamine given to the infant and the mother brings rapid improvement.
- A: B12 deficiency in breastfed infants causes anaemia, hypotonia and regression, not acute heart failure with aphonia.
- B: Riboflavin deficiency causes angular stomatitis and glossitis, not cardiac failure.
- D: Niacin deficiency causes pellagra, a disease of older children and adults.