Question 1 · Hard · Matrix
For each oncology client, indicate the emergency the findings most likely show.
For each row, choose: SIADH / Tumour lysis syndrome / Hypercalcaemia of malignancy
- Leukaemia on induction, uric acid 12 mg/dL, falling urine output
- Small cell lung cancer, weight gain, no oedema, new confusion
- Multiple myeloma, calcium 13.1 mg/dL, lethargy
- Lymphoma treated yesterday, potassium 6.1 mEq/L, phosphate 7.8 mg/dL
- Small cell lung cancer, sodium 121 mEq/L, concentrated urine
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Answer:
- Leukaemia on induction, uric acid 12 mg/dL, falling urine output: Tumour lysis syndrome
- Small cell lung cancer, weight gain, no oedema, new confusion: SIADH
- Multiple myeloma, calcium 13.1 mg/dL, lethargy: Hypercalcaemia of malignancy
- Lymphoma treated yesterday, potassium 6.1 mEq/L, phosphate 7.8 mg/dL: Tumour lysis syndrome
- Small cell lung cancer, sodium 121 mEq/L, concentrated urine: SIADH
Analyse cues: SIADH (often small cell lung cancer) causes dilutional hyponatraemia; tumour lysis after treatment of fast-growing tumours raises potassium, phosphate and uric acid; bone metastases and myeloma cause hypercalcaemia with polyuria and lethargy.
- Leukaemia on induction, uric acid 12 mg/dL, falling urine output: Uric acid crystals injure the kidney.
- Small cell lung cancer, weight gain, no oedema, new confusion: Water retention without oedema and confusion fit SIADH.
- Multiple myeloma, calcium 13.1 mg/dL, lethargy: Bone destruction releases calcium.
- Lymphoma treated yesterday, potassium 6.1 mEq/L, phosphate 7.8 mg/dL: Lysed cells release potassium and phosphate.
- Small cell lung cancer, sodium 121 mEq/L, concentrated urine: Ectopic ADH holds water and dilutes sodium.