Question 1 · Easy
A 66-year-old woman has had a venous ulcer above the left medial malleolus for 15 years. Over 3 months part of the ulcer edge has become raised, everted and indurated, with a foul discharge, and a hard inguinal node is felt. Biopsy of the edge is most likely to show which tumour?
- ABasal cell carcinoma
- BSquamous cell carcinoma
- CMalignant melanoma
- DKaposi sarcoma
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Answer: B · Squamous cell carcinoma
Malignant change in a long-standing chronic ulcer or scar (venous ulcer, burn scar, sinus of osteomyelitis) is a Marjolin ulcer, almost always a squamous cell carcinoma. Clues are a change in the edge (raised, everted, rolled), new growth, bleeding or smell in an ulcer that was stable for years. Any chronic ulcer with these changes needs a biopsy from the edge. A Marjolin ulcer itself is slow growing and painless because the scar has no nerves; once nodes are involved, they need treatment too.
- A: BCC has a rolled pearly edge, usually on the face, and rarely spreads to nodes.
- C: Melanoma is pigmented and is not the classic tumour in a chronic ulcer.
- D: Kaposi sarcoma gives purple plaques and nodules, mainly with HIV.