Question 1 · Medium
A 30-year-old mason is examined two hours after wet cement and lime splashed into his eye; irrigation was done in casualty. A month later his cornea is scarred and vascularised, while a colleague who had battery acid splashed into his eye at work recovered fully. Why do alkali burns usually cause deeper damage than acid burns?
- AAlkalis saponify cell membranes and penetrate
- BAlkalis act only after a delay of some hours
- CAlkalis are always more concentrated than acids
- DAlkalis coagulate surface proteins as a barrier
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Answer: A · Alkalis saponify cell membranes and penetrate
Alkalis such as lime, cement and ammonia saponify the fatty acids of cell membranes, so they pass rapidly through the cornea into the anterior chamber and damage the limbal stem cells, iris, lens and ciliary body. Acids coagulate and precipitate surface proteins, which form a barrier that limits deeper penetration. The extent of limbal ischaemia is a key guide to prognosis, because loss of limbal stem cells leads to vascularisation and scarring. Severe acid burns, however, can still be serious.
- B: Alkali damage begins within seconds, which is why immediate irrigation matters.
- C: The difference is the mechanism, not concentration.
- D: Protein coagulation that limits penetration is the action of acids, not alkalis.