Question 1 · Medium
Escitalopram has kept a teacher's depression in remission for 8 months, but she reports loss of interest in sex and delayed orgasm that are straining her marriage. She does not want to stop treatment. Which change is most likely to relieve this while keeping her mood stable?
- ASwitch to venlafaxine
- BSwitch to paroxetine
- CAdd clomipramine
- DSwitch to bupropion
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Answer: D · Switch to bupropion
SSRIs commonly cause reduced desire, delayed orgasm and anorgasmia. Bupropion (a noradrenaline-dopamine reuptake inhibitor) and mirtazapine have little sexual side effect, so switching to or adding bupropion is a standard strategy. Paroxetine, clomipramine and venlafaxine all have strong serotonergic effects and cause at least as much sexual dysfunction. Key point: Bupropion or mirtazapine are preferred when SSRI-induced sexual dysfunction troubles the patient.
- A: Venlafaxine causes sexual dysfunction similar to SSRIs.
- B: Paroxetine has among the highest rates of sexual dysfunction.
- C: Clomipramine is strongly serotonergic and worsens orgasmic delay.