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A 3-year-old girl has had a swollen, stiff left knee and right ankle for 10 weeks, without fever, rash or eye symptoms, and is diagnosed with oligoarticular juvenile idiopathic arthritis. Results: HEp-2 ANA 1:320, speckled; anti-dsDNA negative; ENA panel (Sm, RNP, SSA, SSB, Scl-70, Jo-1) negative; rheumatoid factor negative; anti-CCP negative; HLA-B27 negative; CRP 9 mg/L (reference < 5 mg/L); CBC, urinalysis, C3 and C4 within reference intervals. What is the main clinical significance of her ANA result?
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