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A 62-year-old man who has never had chemotherapy or radiotherapy presents with fatigue; he has no earlier blood disorder. Hemoglobin 84 g/L (8.4 g/dL), WBC 7.2 × 10^9/L with 18% blasts, platelets 520 × 10^9/L (reference 150-450). The marrow has 34% myeloblasts (CD34+, CD117+, CD13+, CD33+, HLA-DR+, MPO+ in a minority), many small megakaryocytes with one or two nuclear lobes, and dysplastic granulocytes. Karyotype: 45,XY,inv(3)(q21.3q26.2),-7[18]/46,XY[2]. NPM1, CEBPA and FLT3 are not mutated. Under the WHO 5th edition, what is the correct classification?
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