Question 1 · Medium
A woman on apixaban 5 mg twice daily for atrial fibrillation (CHA2DS2-VASc score 3), with creatinine clearance 80 mL/min, is booked for an open liver resection, a high bleeding-risk operation. How should apixaban be handled before surgery?
- AStop on the morning of surgery
- BContinue it through surgery
- CStop 5 days before; bridge with LMWH
- DStop 2 days before; no bridging
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Answer: D · Stop 2 days before; no bridging
Direct oral anticoagulants have short half-lives, so they are stopped for a fixed interval without heparin bridging. With normal renal function, apixaban is held for 1 day before low bleeding-risk surgery and 2 days before high bleeding-risk surgery, as in the PAUSE study. Bridging only adds bleeding. Key point: Hold apixaban 2 days before high bleeding-risk surgery (1 day for low risk); DOACs do not need bridging.
- A: Stopping on the day leaves an anticoagulant effect during surgery.
- B: Continuing a DOAC through major liver surgery risks serious bleeding.
- C: Five days and bridging is the warfarin approach, not for a DOAC.