Question 1 · Hard
Two infants died within a few hours of MR vaccination. Both doses came from a vial reconstituted at the previous day's session. The most likely cause is:
- AToxic shock from a contaminated vial
- BAnaphylaxis to the vaccine
- CVaccine failure from heat exposure
- DCoincidental sudden infant death
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Answer: A · Toxic shock from a contaminated vial
Reconstituted MR vaccine has no preservative and must be discarded 4 hours after mixing or at the end of the session. A vial kept overnight can grow Staphylococcus aureus, which causes toxic shock syndrome with vomiting, fever and death within hours. Clustering of deaths from one vial points to this programme error. It is prevented by strict adherence to the 4-hour rule and by using the supplied diluent.
- B: Anaphylaxis occurs within minutes and is very rare, and would not explain the shared old vial.
- C: Heat exposure lowers potency but does not kill within hours.
- D: Two deaths from one vial make coincidence unlikely.