Question 1 · Medium
A term newborn in the labour room has severe breathing difficulty from birth. The abdomen is scaphoid, breath sounds are absent on the left, heart sounds are heard on the right, and the X-ray shows bowel loops in the left hemithorax. Which developmental failure is most likely?
- ASeptum transversum failing to fuse anteriorly
- BPleuroperitoneal membrane failing to close
- CDiaphragm muscle failing to develop in the central tendon
- DOesophageal hiatus forming too wide
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Answer: B · Pleuroperitoneal membrane failing to close
This is a congenital diaphragmatic hernia of the Bochdalek type, a posterolateral defect, usually on the left. It results from failure of the pleuroperitoneal membrane to close the pericardioperitoneal canal, so gut herniates into the chest and compresses the developing lung, leading to pulmonary hypoplasia and pulmonary hypertension. The baby is intubated rather than ventilated by bag and mask, and a nasogastric tube decompresses the gut.
- A: An anterior defect beside the sternum from the septum transversum region is a Morgagni hernia.
- C: The central tendon is not muscular; absent muscle causes eventration, not a posterolateral defect.
- D: A wide oesophageal hiatus gives a hiatus hernia, not bowel filling the chest at birth.