Question 1 · Medium
A 45-year-old daily-wage worker weighing 52 kg has had a cough for 3 weeks. Sputum NAAT at the block PHC detects Mycobacterium tuberculosis with rifampicin resistance not detected, and line probe assay later shows isoniazid susceptibility. He has never taken anti-TB treatment. Which regimen does NTEP prescribe?
- A2 months HRZE, then 4 months HR daily
- B6 months BPaLM daily
- C2 HRZES, 1 HRZE, then 5 HRE daily
- D2 months HRZE, then 4 months HRE daily
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Answer: D · 2 months HRZE, then 4 months HRE daily
Under NTEP, drug-sensitive TB (new or previously treated) gets the same daily regimen: 2 months of isoniazid, rifampicin, pyrazinamide and ethambutol, then 4 months of isoniazid, rifampicin and ethambutol, as weight-band fixed-dose combinations. India keeps ethambutol in the continuation phase, unlike the WHO standard of 4 months HR. The old Category II regimen with streptomycin has been withdrawn. BPaLM (bedaquiline, pretomanid, linezolid, moxifloxacin) is the shorter regimen for eligible patients with MDR/RR-TB, not for drug-sensitive disease.
- A: Continuation with HR alone is the WHO regimen; NTEP adds ethambutol.
- B: BPaLM is for MDR/RR-TB, and this strain is drug-sensitive.
- C: The streptomycin-based Category II regimen is no longer used.