Question 1 · Easy
A 3-month-old exclusively breastfed baby in a coastal village is brought to a PHC with sudden breathlessness, vomiting, a weak hoarse cry and a fast pulse; the liver is enlarged. The mother lives mostly on highly polished rice and has numbness of her feet. Which deficiency is the most likely cause?
- AVitamin B1 (thiamine)
- BVitamin B12 (cobalamin)
- CVitamin B2 (riboflavin)
- DVitamin B3 (niacin)
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Answer: A · Vitamin B1 (thiamine)
Infantile beriberi affects breastfed babies aged about 2-6 months whose mothers are thiamine deficient, as here (a polished-rice diet and maternal peripheral neuropathy). The acute cardiac form causes sudden heart failure with tachycardia, breathlessness and hepatomegaly, and an aphonic or hoarse cry is typical. Milling and washing remove thiamine from rice, while parboiling preserves it. Thiamine given promptly to the baby and the mother reverses the illness, and untreated cardiac beriberi can kill within hours.
- B: Infant B12 deficiency causes anaemia and developmental regression, not acute heart failure.
- C: Riboflavin deficiency causes angular stomatitis and glossitis, not heart failure.
- D: Niacin deficiency causes pellagra with dermatitis, diarrhoea and dementia.