Question 1 · Medium
Arrange these Krebs' cycle intermediates in the order of their formation, starting after acetyl CoA joins oxaloacetic acid. A. α-ketoglutaric acid B. Malic acid C. Citric acid D. Succinic acid
- AC, A, B, D
- BC, A, D, B
- CC, D, A, B
- DA, C, D, B
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Answer: B · C, A, D, B
Acetyl CoA and oxaloacetic acid condense to form citric acid (6C). Citric acid gives α-ketoglutaric acid (5C), then succinyl CoA and succinic acid (4C), then malic acid, which forms oxaloacetic acid again.
- A: Malic acid forms after succinic acid, on the way to oxaloacetic acid.
- C: This places a 4C acid before the 5C acid.
- D: Citric acid is the first product, before α-ketoglutaric acid.
Remember this
Carbon count falls 6C, 5C, 4C; oxaloacetic acid is regenerated and joins the next acetyl CoA.
Mnemonic: Citrate Is Krebs' Starting Substrate For Making Oxaloacetate (citrate, isocitrate, α-ketoglutarate, succinyl-CoA, succinate, fumarate, malate, oxaloacetate).